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KMID : 0380620150470030394
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Korean Journal of Food Science and Technology
2015 Volume.47 No. 3 p.394 ~ p.400
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Anti-atopic Effect of Hot Water and Supercritical Carbon Dioxide Fluid Extract of Persimmon (Diospyros kaki) Peels
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Cho Byoung-Ok
Yin Hong-Hua
Fang Chong-Zhou
Shin Jae-Young
Ha Hye-Ok
Kim Sang-Jun
Jeong Seung-Il
Jang Seon-Il
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Abstract
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This study aimed to investigate the anti-atopic effect of hot water (PPWE) and supercritical-carbon dioxide fluid extract of persimmon peels (SPPE) on atopic dermatitis (AD)-like skin lesions in hairless mice. Histological analyses demonstrated that SPPE treatment more strongly inhibited the dermal infiltration of inflammatory cells in AD-like skin lesions than that by PPWE. Compared to PPWE, SPPE significantly decreased the dermatitis clinical score and the epidermal thickness and potently suppressed serum IgE and interleukin (IL)-4 production in hairless mice with AD. Furthermore, compared to PPWE, SPPE potently inhibited the production of nitric oxide, prostaglandin E2, and proinflammatory cytokines such as IL-6 and IL-1β in lipopolysaccharide-stimulated RAW264.7 macrophages. These results suggested that SPPE exhibited anti-atopic dermatitis activity via the regulation of inflammatory responses.
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KEYWORD
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persimmon peels, supercritical fluid extract, atopic dermatitis, anti-inflammation
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